Endothelin (ET) – 1 was discovered in 1988. Scientists and clinicians were quick to identify it as a very important molecule given it was present in all humans and its levels are significantly elevated in different diseases. This includes different cancers, neurodegenerative diseases, cardiovascular diseases as well as diabetes. ET-1 is largely responsible for many pathological processes in these diseases.
Endothelin-1 is a vasoconstrictor, proinflammatory and proliferative endothelial cell-derived peptide that is of significant importance in the regulation of vascular function.
Different studies show that endothelin-1 levels are pathologically elevated in different diseases. These include different neurological disorders, diabetes cardiovascular diseases, different cancers and pregnancy disorders, such as pre-eclampsia. The following page discusses these in more detail.
A lot of studies including the ones above/on the next page talk about the importance of lowering endothelin-1 levels.
However, endothelin-1 is critical for normal physiological functions and using an endothelin antagonist that completely blocks the activity of endothelin-1 is associated with many side effects.
It might be more useful to merely sequester the pathologically elevated levels of endothelin-1. The next page lists different foods that can help lower endothelin-1 levels.